منابع مشابه
Astrocyte Function in Alcohol Reward and Addiction
Glial cells, particularly astrocytes, play essential roles in the regulation of neurotransmission, metabolism, and supply of energy substrates for synaptic transmission. One astrocyte can receive inputs from several hundreds of synapses, and synchronized neuronal activity correlates with astrocyte calcium signaling. Astrocyte pathology is a common feature of ethanol exposure in both humans and ...
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Morphine is the most potent analgesic for chronic pain, but its clinical use has been limited by the opiate's innate tendency to produce tolerance, severe withdrawal symptoms and rewarding properties with a high risk of relapse. To understand the addictive properties of morphine, past studies have focused on relevant molecular and cellular changes in the brain, highlighting the functional roles...
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The high recrudescence rate of drug addiction has received attention worldwide and its mechanisms remain to be elucidated. This study aimed to analyse the disparate protein expression in the hippocampal tissue of rats with recrudescence of morphine addiction, as well as to provide clues for the exploration of the recrudescence mechanism. Sixteen male adult Sprague-Dawley rats were divided equal...
متن کاملNeurobiology of addiction neuroanatomical, neurochemical, molecular and genetic aspects of morphine and cocaine addiction PART I
Leff, Philippe; Medina, Ma. Elena; Calva, Juan Carlos; Valdés, Armando; Acevedo, Rodolfo; Morales, Aline; Medécigo, Mayra; Antón, Benito Neurobiology of addiction neuroanatomical, neurochemical, molecular and genetic aspects of morphine and cocaine addiction. Part I Salud Mental, vol. 23, núm. 3, junio, 2000, pp. 46-51 Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Distrito Federal,...
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Drugs of abuse, including opiates and psychostimulants, induce both short and long-lasting effects on behavior and similarly exert profound changes in the neural circuits where these drugs operate producing neuronal adaptations and long term changes in synaptic plasticity. Such neuroadaptation occur as homestatic responses to excessive drug stimulation in assotiation with a specific pattern of ...
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ژورنال
عنوان ژورنال: Journal of Proteome Research
سال: 2009
ISSN: 1535-3893,1535-3907
DOI: 10.1021/pr900759w